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SMACKS

SMACKS is a maximum likelihood approach to extract kinetic rate models from noisy single molecule data.

SMACKS (Single Molecule Analysis of Complex Kinetic Sequences) is a maximum likelihood approach to extract kinetic rate models from noisy single molecule data.
Please find the full paper here: Experiment-friendly kinetic analysis of single molecule data in and out of equilibrium.
While fine-tuned for FRET data, SMACKS is applicable to single molecule time traces of any kind. It is based on multidimensional semi-ensemble HMM.

 
The SMACKS software tool comes with the complete source code, a detailed manual, an ascii importer & example data for testing.

Please enter your email address to download the software tool (It will be used for update announcements only). By doing so you accept the MIT software license.

 

Please cite the publication above if SMACKS was useful to your work.

Feedback and bug reports are appreciated: smacks@pc.uni-freiburg.de

SMACKS screenshot2

SMACKS screenshot1