Publications
→ 2024→ 2023,→ 2022,→ 2021,→ 2020, → 2019, → 2018, → 2017, → 2016, → 2015, → 2014, → 2013, → 2012, → 2011, → 2010, → 2009, → 2008, → 2007, → 2006, → 2005, → 2003, → 2002, → 2001, → 2000, → 1999
JoVE Video: Investigating single molecule adhesion by atomic force spectroscopy
JoVE Video: Using three-color single-molecule FRET to study the correlation of protein interactions
JoVE Video: Covalent attachment of single molecules for AFM-based force spectroscopy
2024
D. Huang, T. Hugel & G. Reiter
Mechanism for the Formation of Millimeter-Long Solid Filaments by Spin Coating Dilute Solutions of a Crystallizable Polymer
Macromolecules (2024). https://doi.org/10.1021/acs.macromol.3c02524
L.Vollmar, J. Schimpf, B. Hermann & T.Hugel
Cochaperones convey the energy of ATP hydrolysis for directional action of Hsp90
Nat. Commun. (2024), https://doi.org/10.1038/s41467-024-44847-6
2023
M. Lallemang, C. O. Akintayo, C. Wenzel, W. Chen, L. Sielaff, A. Ripp, H. J. Jessen, B. N. Balzer, A. Walther & T. Hugel
Hierarchical Mechanical Transduction of Precision-Engineered DNA Hydrogels with Sacrificial Bonds
ACS Applied Materials & Interfaces, 15 (51), 59714 (2023). https://doi.org/10.1021/acsami.3c15135
K. Dai, M. D. Pol, L. Saile, A. Sharma, B. Liu, R. Thomann, J. L. Trefs, D. Qiu, S. Moser, S. Wiesler, B. N. Balzer, T. Hugel, H. J. Jessen & C. G. Pappas
Spontaneous and Selective Peptide Elongation in Water Driven by Aminoacyl Phosphate Esters and Phase Changes
J. Am. Chem. Soc., 145 (48), 26086, (2023). https://doi.org/10.1021/jacs.3c07918
M. Ibrahim, C. Wenzel, M. Lallemang, B. N. Balzer & N. Schwierz
Adsorbing DNA to Mica by Cations: Influence of Valency and Ion Type
Langmuir, 39 (44), 15553 (2023). https://doi.org/10.1021/acs.langmuir.3c01835
Biophys J (2023). https://doi.org/10.1016/j.bpj.2023.07.020
T. Mondol, B. Sohmen & T. Hugel
Single molecule fluorescence methods for molecular chaperones and their client interactions
Book Chapter, RCS publishing, Editors: Lichun He, Sebastian Hiller and Maili Liu, (2023).
https://doi.org/10.1039/BK9781839165986-00181
F. J. Gatti, W. Cai, R. Herzog, A. Gharavian, A. Kailer, N. Baltes, P. Rabenecker, P. Mörchel, B. N. Balzer, T. Amann & J. Rühe
Investigation of programmable friction with ionic liquid mixtures at the nano- and macroscales
Lubricants, 11(9), 376 (2023). https://doi.org/10.3390/lubricants11090376
C. Lan, J. Kim, S. Ulferts, F. Aprile-Garcia, S. Weyrauch, A. Anandamurugan, R. Grosse, R. Sawarkar, A. Reinhardt & T. Hugel
Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation
Nat. Commun., 14, 4831 (2023). https://doi.org/10.1038/s41467-023-40540-2
K. Dai, M. D. Pol, L. Saile, A. Sharma, B. Liu, R. Thomann, J. L. Trefs, D. Qiu, S. Moser, S. Wiesler, B. N. Balzer, T. Hugel, H. J. Jessen & C. G. Pappas
Systems chemistry of aminoacyl phosphates: Spontaneous and selective peptide oligomerisation in water driven by phase changes
chemRxiv (2023). https://doi.org/10.26434/chemrxiv-2023-lg3cw
M. Ibrahim, C. Wenzel, M. Lallemang, B. N. Balzer & N. Schwierz
Adsorbing DNA to mica by cations: Influence of the valency and ion type
bioRxiv (2023). https://doi.org/10.1021/acs.langmuir.3c01835
W. Cai, M. Jäger, J. T. Bullerjahn, T. Hugel, S. Wolf & B. N. Balzer
Anisotropic friction in a ligand-protein complex
Nano Lett., 23 (10), 4111 (2023). https://doi.org/10.1021/acs.nanolett.2c04632, Cover
G. Adam et al.
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins
Nature Methods, (2023). https://doi.org/10.1038/s41592-023-01807-0
W. Cai, J. L. Trefs, T. Hugel & B.N. Balzer
Anisotropy of π–π stacking as basis for superlubricity
ACS Materials Lett., 5 (1), 172 (2023). https://doi.org/10.1021/acsmaterialslett.2c00974
2022
M. Marczynski, T. M. Lutz, R. Schlatterer, M. Henkel, B. N. Balzer & O. Lieleg
Contamination with black carbon nanoparticles alters the selective permeability of mucin hydrogels: Implications for molecular transport across mucosal barriers
ACS Appl. Nano Mater., 5 (11), 16955 (2022). https://doi.org/10.1021/acsanm.2c03887
M. Götz et al.
A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories
Nat. Commun., 13, 5402 (2022). https://doi.org/10.1038/s41467-022-33023-3
L. Gemmer, Q. Hu, B. Niebuur, T. Kraus, B. N. Balzer & M. Gallei
A block copolymer templated approach for the preparation of nanoporous polymer structures and cellulose fiber hybrids by ozone treatment
Polym. Chem., 13, 4028 (2022). https://doi.org/10.1039/D2PY00562J
M. Tschaikowsky, S. Brander, V. Barth, R. Thomann, B. Rolauffs, B.N. Balzer & T. Hugel
The articular cartilage surface is impaired by a loss of thick collagen fibers and formation of type I collagen in early osteoarthritis
Acta Biomaterialia, 146, 274 (2022). https://doi.org/10.1016/j.actbio.2022.04.036
W. Cai, J.T. Bullerjahn, M. Lallemang, K. Kroy, B.N. Balzer & T. Hugel
Angle-dependent strength of a single chemical bond by stereographic force spectroscopy
Chemical Science, 13, 5734 (2022). https://doi.org/10.1039/D2SC01077A
A. Goralczyk, M. Zhu, F. Mayoussi, M. Lallemang, M. Tschaikowsky, A. Warmbold, S. Caliaro, F. Tauber, B. N. Balzer, F. Kotz-Helmer, D. Helmer & B. E. Rapp
Study of repellence on polymeric surfaces with two individually adjustable pore hierarchies
Chemical Engineering Journal, 437 (1), 135287 (2022). https://doi.org/10.1016/j.cej.2022.135287
M. Lallemang, L. Yu, W. Cai, K. Rischka, A. Hartwig, R. Haag, T. Hugel & B. N. Balzer
Multivalent non-covalent interactions lead to strongest polymer adhesion
Nanoscale, 14, 3768 (2022). http://dx.doi.org/10.1039/D1NR08338D
A. Baldwin, M. Hartl, M. Tschaikowsky, B.N. Balzer & B.W. Booth
Degradation and release of tannic acid from an injectable tissue regeneration bead matrix in vivo
J Biomed Mater Res., 110, 1165 (2021). https://doi.org/10.1002/jbm.b.34990
F. V. Frieß, Q. Hu, J. Mayer, L. Gemmer, V. Presser, B. N. Balzer & M. Gallei
Nanoporous block copolymer membranes with enhanced solvent resistance via UV-mediated cross-linking strategies
Macromol. Rapid Commun., 43, 2100632 (2022). https://doi.org/10.1002/marc.202100632
2021
P. Lohner, M. Zmyslia, J. Thurn, J. K. Pape, R. Gerasimaitė, J. Keller-Findeisen, S. Groeer, B. Deuringer, R. Süss, A. Walther, S. W. Hell, G. Lukinavičius, T. Hugel & C. Jessen-Trefzer
Inside a shell-Organometallic catalysis inside encapsulin nanoreactors
Angew. Chem. Int. Ed., 60, 23835 (2021). https://doi.org/10.1002/anie.202110327
J. Nuno de Sousa Machado, L. Vollmar, J. Schimpf, P. Chaudhury, R. Kumariya, C. van der Does, T. Hugel & S. V. Albers
Autophosphorylation of the KaiC-like protein ArlH inhibits oligomerization and interaction with ArlI, the motor ATPase of the archaellum
Mol. Microbiol., 116(3), 943 (2021). http://doi.org/10.1111/mmi.14781
E. Lerner et al.
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices
eLife, 10:e60416 (2021). https://doi.org/10.7554/eLife.60416
M. Tschaikowsky, T. Neumann, S. Brander, H. Haschke, B. Rolauffs, B.N. Balzer & T. Hugel
Hybrid fluorescence-AFM explores articular surface degeneration in early osteoarthritis across length scales
Acta Biomaterialia, 126, 315 (2021). https://doi.org/10.1016/j.actbio.2021.03.034
S. Wolf, B. Sohmen, B. Hellenkamp, J. Thurn, G. Stock & T. Hugel
Hierarchical dynamics in allostery following ATP hydrolysis monitored by single molecule FRET measurements and MD simulations
Chem. Sci. 12, 3350 (2021). https://doi.org/10.1039/D0SC06134D
M. Tschaikowsky, M. Selig, S. Brander, B.N. Balzer, T. Hugel & B. Rolauffs
Proof-of-concept for the detection of early osteoarthritis pathology by clinically applicable endomicroscopy and quantitative AI-supported optical biopsy
Osteoarthritis and Cartilage, 29 (2), 269 (2021). https://doi.org/10.1016/j.joca.2020.10.003
2020
H. Wang, M. Lallemang, B. Hermann, C. Wallin, R. Loch, A. Blanc, B.N. Balzer, T. Hugel & J. Luo
ATP impedes the inhibitory effect of Hsp90 on Aβ40 fibrillation
J. Mol. Biol., S0022-2836, 20, 30635-5 (2020). https://doi.org/10.1016/j.jmb.2020.11.016
S. Schmid & T. Hugel
Controlling protein function by fine-tuning conformational flexibility
eLife, 9, 1013 (2020). https://doi.org/10.7554/eLife.57180
A. Kolberg, C. Wenzel, T. Hugel, M. Gallei & B.N. Balzer
Covalent attachment of single molecules for AFM-based force spectroscopy
J. Vis. Exp., 157, e60934 (2020). https://doi.org/10.3791/60934
Colloids and Surfaces B: Biointerfaces, 187, 110614 (2020). https://doi.org/10.1016/j.colsurfb.2019.110614
2019
A. Kolberg, C. Wenzel, K. Hackenstrass, R. Schwarzl, C. Rüttiger, T. Hugel, M. Gallei, R.R. Netz & B.N. BalzerOpposing temperature dependence of the stretching response of single PEG and PNiPAM polymers
J. Am. Chem. Soc., 141 (29), 11603 (2019). https://doi.org/10.1021/jacs.9b04383
H. Schafer, A. Kolberg, M. Gockeln, R. Kun, B.N. Balzer & K. Koschek
Influence of free PCL in PCL/PBA-a copolymers and blends on morphology, thermo-mechanical and shape memory properties
Polymer Testing, 77, 105888 (2019). https://doi.org/10.1016/j.polymertesting.2019.05.004
S. Brander, T. Jank & T.Hugel
AFM imaging suggests receptor-free penetration of lipid bilayers by toxins
Langmuir, 35 (2), 365 (2019). https://pubs.acs.org/doi/10.1021/acs.langmuir.8b03146
2018
B. Hellenkamp, J. Thurn, M. Stadlmeier & T.Hugel
Kinetics of transient protein complexes determined via diffusion-independent microfluidic mixing and fluorescence stoichiometry
J. Phys. Chem. B, 122 (49), 11554 (2018). https://doi.org/10.1021/acs.jpcb.8b07437
K.M. Tych, M. Jahn, F. Gegenfurtner, V.K. Hechtl, J. Buchner, T. Hugel & M. Rief
Nucleotide-dependent dimer association and dissociation of the chaperone Hsp90
J. Phys. Chem. B, 122 (49), 11373 (2018). https://doi.org/10.1021/acs.jpcb.8b07301
B. Hellenkamp, S. Schmid, et int. & T. Hugel
Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study
Nat Methods,15, 669-676 (2018). Open access: https://www.nature.com/articles/s41592-018-0085-0
W. Ye, M. Götz, S. Celiksoy, L. Tüting, C. Ratzke, J. Prasad, J. Ricken, S.V. Wegner, R. Ahijado-Guzmán, T. Hugel & C. Sönnichsen
Conformational dynamics of a single protein monitored for 24 h at video rate
Nano Lett., 18 (10), 6633 (2018). https://doi.org/10.1021/acs.nanolett.8b03342
Open access: https://pubs.acs.org/doi/10.1021/acs.nanolett.8b03342
M. Jahn, K. Tych, H. Girstmair, M. Steinmaßl, T. Hugel, J. Buchner & M. Rief
Folding and domain interactions of three orthologs of Hsp90 studied by single-molecule force spectroscopy
Structure 26 (1), 96 (2018). https://doi.org/10.1016/j.str.2017.11.023
S. Schmid, M. Götz & T. Hugel
Effects of inhibitors on Hsp90's conformational dynamics, cochaperone and client interactions
ChemPhysChem, 19 (14), 1716 (2018). https://doi.org/10.1002/cphc.201800342
S. Schmid & T. Hugel
Efficient use of single molecule time traces to resolve kinetic rates, models and uncertainties
J. Chem. Phys., 148, 123312 (2018). https://doi.org/10.1063/1.5006604
M. Götz, P. Wortmann, S. Schmid & T. Hugel
Using three-color single-molecule FRET to study the correlation of protein interactions
J. Vis. Exp. 131, e56896 (2018). https://doi.org/10.3791/56896
2017
P. Wortmann, M. Götz & T. Hugel
Cooperative nucleotide binding in Hsp90 and its regulation by Aha1
Biophys J., 113 (8), 1711 (2017). https://doi.org/10.1016/j.bpj.2017.08.032
B. Winkeljann, K. Boettcher, B.N. Balzer & O. Lieleg
Mucin coatings prevent tissue damage at the cornea-contact lens interface
Adv. Mater. Interfaces, 4 (19), 1700186 (2017). https://doi.org/10.1002/admi.201700186
S. Liese, M. Gensler, S. Krysiak, R. Schwarzl, A. Achazi, B. Paulus, T. Hugel, J. Rabe & R. Netz
Hydration effects turn a highly stretched polymer from an entropic into an energetic spring
ACS Nano, 11 (1), 702 (2017). https://doi.org/10.1021/acsnano.6b07071
B. Hellenkamp, P. Wortmann, F. Kandzia, M. Zacharias & T. Hugel
Multidomain structure and correlated dynamics determined by self-consistent FRET networks
Nat Methods, 14 (2), 174 (2017). https://doi.org/10.1038/nmeth.4081
2016
K. Boettcher, S. Kienle, J. Nachtsheim, R. Burgkart, T. Hugel & O. Lieleg
The structure and mechanical properties of articular cartilage are highly resilient towards transient dehydration
Acta Biomaterialia, 29, 180 (2016). https://doi.org/10.1016/j.actbio.2015.09.034
M. Götz, P. Wortmann, S. Schmid & T. Hugel
A multicolor single-molecule FRET approach to study protein dynamics and interactions simultaneously
Methods Enzymol., 581, 487 (2016). https://doi.org/10.1016/bs.mie.2016.08.024
S. Schmid, M. Götz & T. Hugel
Single-molecule analysis beyond dwell times: Demonstration and assessment in and out of equilibrium
Biophysical J., 111 (7), 1375 (2016). https://doi.org/10.1016/j.bpj.2016.08.023
F. Stetter, S-H. Hyun, S. Brander, J. Urban, D. Thompson & T. Hugel
Nanomechanical characterization of lipid bilayers with AFM-based methods
Polymer, 102, 326 (2016). https://doi.org/10.1016/j.polymer.2015.11.038
N. Schwierz, S. Krysiak, T. Hugel & M. Zacharias
Mechanism of reversible peptide-bilayer attachment: Combined simulation and experimental single-molecule study
Langmuir, 32 (3), 810 (2016). https://doi.org/10.1021/acs.langmuir.5b03435
M. Jahn, J. Buchner, T. Hugel & M. Rief
Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments
PNAS, 113 (5), 1232 (2016).
B.N. Balzer & T. Hugel
Single-molecule detection and manipulation
In: Saleem Hashmi (editor-in-chief); Reference Module in Materials Science and Materials Engineering. Oxford: Elsevier pp. 1-19 (2016)
2015
B. Kracke, J. Cole, C. Kaiser, B. Hellenkamp, S. Krysiak, A. Ghoorchian, G. Braun, N. Holland & T. Hugel
Thermoswitchable nanoparticles based on elastin-like polypeptides
Macromolecules, 48 (16), 5868 (2015). https://doi.org/10.1021/acs.macromol.5b00932
S. Kienle, K. Boettcher, L. Wiegleb, J. Urban, R. Burgkart, O. Lieleg & T. Hugel
Comparison of friction and wear of articular cartilage on different length scales
J. Biomech., 48 (12), 3052 (2015). https://doi.org/10.1016/j.jbiomech.2015.07.027
S. Krysiak, Q. Wei, K. Rischka, A. Hartwig, R. Haag & T. Hugel
Adsorption mechanism and valency of catechol-functionalized hyperbranched polyglycerols
Beilstein J. Org. Chem., 11, 828 (2015). https://doi.org/10.3762/bjoc.11.92
F. Stetter, S. Kienle, S. Krysiak & T. Hugel
Investigating single molecule adhesion by atomic force spectroscopy
J. Vis. Exp., 96, e52456 (2015). https://doi.org/10.3791/52456
2014
C. Ratzke, B. Hellenkamp & T. Hugel
Four-colour FRET reveals directionality in the Hsp90 multicomponent machinery
Nat Commun., 5, 4192 (2014). https://doi.org/10.1038/ncomms5192
Research Highlight:
Four-color FRET follows Hsp90 states
Nat Methods, 11, 791 (2014). https://doi.org/10.1038/nmeth.3051
M. Jahn, A. Rehn, B. Pelz, B. Hellenkamp, K. Richter, M. Rief, J. Buchner & T. Hugel
The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function
PNAS, 111 (50), 17881 (2014).
S. Schwenkert, T. Hugel & M. B. Cox
The Hsp90 ensemble: coordinated Hsp90–cochaperone complexes regulate diverse cellular processes
Nat Struct Mol Biol, 21 (12), 1021 (2014). https://doi.org/10.1038/nsmb.2927
S. Krysiak, S. Liese, R.R. Netz & T. Hugel
Peptide desorption kinetics from single molecule force spectroscopy studies
J. Am. Chem. Soc., 136 (2), 688 (2014). https://doi.org/10.1021/ja410278r
B.N. Balzer, S. Kienle, M. Gallei, R. v. Klitzing, M. Rehahn & T. Hugel
Stick-slip mechanisms at the nanoscale
Soft Materials, 12 (1), 106 (2014). https://doi.org/10.1080/1539445X.2014.945039
Q. Wei, S. Krysiak, K. Achazi, T. Becherer, P.-L.M. Noeske, F. Paulus, H. Liebe, I. Grunwald, J. Dernedde, A. Hartwig, T. Hugel & R. Haag
Multivalent anchored and crosslinked hyperbranched polyglycerol monolayers as antifouling coating for titanium oxide surfaces
Colloids and Surfaces B: Biointerfaces, 122, 684 (2014). https://doi.org/10.1016/j.colsurfb.2014.08.001
F.W.S. Stetter, L. Cwiklik, P. Jungwirth & T. Hugel
Single lipid extraction: The anchoring strength of cholesterol in liquid-ordered and liquid-disordered phases
Biophys J., 107 (5), 1167 (2014). https://doi.org/10.1016/j.bpj.2014.07.018
S. Kienle, M. Gallei, H. Yu, B. Zhang, S. Krysiak, B.N. Balzer, M. Rehahn, A.D. Schlüter & T. Hugel
Effect of molecular architecture on single polymer adhesion
Langmuir, 30 (15), 4351 (2014). https://doi.org/10.1021/la500783n
C. Lumme, et al.
Nucleotides and substrates trigger the dynamics of the Toc34 GTPase homodimer involved in chloroplast preprotein translocation
Structure, 22 (4), 526 (2014). https://doi.org/10.1016/j.str.2014.02.004
J. Elbert, F. Krohm, C. Rüttiger, S. Kienle, H. Didzoleit, B.N. Balzer, T. Hugel, B. Stühn, M. Gallei & A. Brunsen
Polymer-modified mesoporous silica thin films for redox-mediated selective membrane gating
Adv. Funct. Mater., 24 (11), 1591 (2014). https://doi.org/10.1002/adfm.201302304
S. Hertrich, F.W.S. Stetter, A. Rühm, T. Hugel & B. Nickel
Highly hydrated deformable polyethylene glycol-tethered lipid bilayers
Langmuir, 30 (31), 9442 (2014). https://doi.org/10.1021/la4045804
2013
B.N. Balzer, M. Gallei, K. Sondergeld, M. Schindler, P. Müller-Buschbaum, M. Rehahn & T. Hugel
Cohesion mechanisms of polystyrene-based thin polymer films
Macromolecules, 46 (18), 7406 (2013). https://doi.org/10.1021/ma401173y
B.N. Balzer, S. Micciulla, S. Dodoo, M. Zerball, M. Gallei, M Rehahn, R. v. Klitzing & T. Hugel
Adhesion property profiles of supported thin polymer films
ACS Applied Materials & Interfaces, 5 (13), 6300 (2013). https://doi.org/10.1021/am4013424
B.N. Balzer, M. Gallei, M. Hauf, M. Stallhofer, L. Wiegleb, A. Holleitner, M. Rehahn & T. Hugel
Nanoscale friction mechanisms at solid-liquid interfaces
Angew. Chem. Int. Ed., 52 (25), 6541 (2013). https://doi.org/10.1002/anie.201301255
B.N. Balzer, M. Gallei, M. Hauf, M. Stallhofer, L. Wiegleb, A. Holleitner, M. Rehahn & T. Hugel
Reibungsmechanismen auf der Nanoskala an Fest‐flüssig‐Grenzflächen
Angew. Chem., 2013, 125, 6670 (2013). https://doi.org/10.1002/ange.201301255
M. Khaneft, B. Stühn, J. Engstler, H. Tempel, J. Schneider, T. Pirzer & T. Hugel
Imbibition of polystyrene melts in aligned carbon nanotube arrays
J. Appl. Phys., 113, 074305 (2013). https://doi.org/10.1063/1.4793087
S. Kienle, T. Pirzer, S. Krysiak, M. Geisler & T. Hugel
Measuring the interaction between ions, biopolymers and interfaces – one polymer at a time
Faraday Discuss.,160, 329 (2013). https://doi.org/10.1039/C2FD20069D
F.W.S. Stetter & T. Hugel
The nanomechanical properties of lipid membranes are significantly influenced by the presence of ethanol
Biophys J., 104 (5), 1049 (2013). https://doi.org/10.1016/j.bpj.2013.01.021
S. Dodoo, B.N. Balzer, T. Hugel, A. Laschewsky & R. v. Klitzing
Effect of ionic strength and layer number on swelling of polyelectrolyte multilayers in water vapour
Soft Materials, 11(2), 157 (2013). https://doi.org/10.1080/1539445X.2011.607203
2012
N. Schwierz, D. Horinek, S. Liese, T. Pirzer, B.N. Balzer, T. Hugel & R.R. Netz
On the relationship between peptide adsorption resistance and surface contact angle: A combined experimental and simulation single-molecule study
J. Am. Chem. Soc., 134 (48), 19628 (2012). https://doi.org/10.1021/ja304462u
C. Ratzke, M. N. T. Nguyen, M. P. Mayer & T. Hugel
From a ratchet mechanism to random fluctuations evolution of Hsp90's mechanochemical cycle
J Mol Biol., 423 (3), 462 (2012). https://doi.org/10.1016/j.jmb.2012.07.026
S. Kienle, S. Liese, N. Schwierz, R.R. Netz & T.Hugel
The effect of temperature on single polypeptide adsorption
ChemPhysChem, 13 (4), 982 (2012). https://doi.org/10.1002/cphc.201100776
C. Ratzke, F. Berkemeier & T. Hugel
Hsp90's mechano-chemical cycle is dominated by thermal fluctuations
PNAS, 109 (1), 161 (2012).
B.N. Balzer & T. Hugel
Surface & Interface Characterization: Single molecule detection and manipulation
Polymer Science: A Comprehensive Reference; Elsevier: Amsterdam; pp. 629-645 (2012)
2011
D. Staple, M. Geisler, T. Hugel, L. Kreplak & H. Kreuzer
Forced desorption of polymers from interfaces
New J. Phys., 13, 013025 (2011). https://doi.org/10.1088/1367-2630/13/1/013025
S. Schmid & T. Hugel
Regulatory posttranslational modifications in Hsp90 can be compensated by cochaperone Aha1
Mol Cell., 41 (6), 619 (2011). https://doi.org/10.1016/j.molcel.2011.02.028
2010
M. Geisler, S.B. Xiao, E.M. Puchner, F. Gräter & T. Hugel
Controlling the structure of proteins at surfaces
J. Am. Chem. Soc., 132 (48), 17277 (2010). https://doi.org/10.1021/ja107212z
C. Ratzke, M. Mickler, B. Hellenkamp, J. Buchner & T. Hugel
The dynamics of Hsp90 C-terminal dimerization is an important part of its conformational cycle
PNAS, 107 (37), 16101 (2010).
T. Hugel & C. Lumme
Bio-inspired novel design principles for artificial molecular motors
Curr. Opin. Biotechnol., 21 (5), 683 (2010). https://doi.org/10.1016/j.copbio.2010.06.003
I. Amin, M. Steenackers, N. Zhang, A. Beyer, X. Zhang, T. Pirzer, T. Hugel, R. Jordan & A. Gölzhäuser
Polymer carpets
Small, 6 (15), 1623 (2010). https://doi.org/10.1002/smll.201000448
M. Geisler & T. Hugel
Aging of hydrogenated and oxidized diamond
Adv. Mater., 22 (3), 398 (2010). https://doi.org/10.1002/adma.200902198
M. Geisler, R.R. Netz & T. Hugel
Pulling a single molecule off a substrate reveals binding thermodynamics of cosolutes
Angew. Chem. Int. Ed., 49 (28), 4730 (2010). https://doi.org/10.1002/anie.200907098
M. Geisler, R.R. Netz & T. Hugel
Abziehen eines einzelnen Polymers von einem Substrat erschließt thermodynamische Parameter der Kosolutbindung
Angew. Chem., 122 (28), 4838 (2010). https://doi.org/10.1002/ange.200907098
2009
M. Geisler, B.N. Balzer & T. Hugel
Polymer adhesion at the solid-liquid interface probed by a single-molecule force sensor
Small, 5 (24), 2864 (2009). https://doi.org/10.1002/smll.200901237
M. Geisler, D. Horinek & T. Hugel
Single molecule adhesion mechanics on rough surfaces
Macromolecules, 42 (23), 9338 (2009). https://doi.org/10.1021/ma9017372
T. Pirzer & T. Hugel
Adsorption mechanism of polypeptides and their location at hydrophobic iInterfaces
ChemPhysChem, 10 (16), 2795 (2009). https://doi.org/10.1002/cphc.200900574
T. Pirzer & T. Hugel
AFM spring constant determination in viscous liquids
Rev. Sci. Instrum., 80 (3), 035110 (2009). https://doi.org/10.1063/1.3100258
T. Pirzer, M. Geisler, T. Scheibel & T. Hugel
Single molecule force measurements delineate salt, pH and surface effects on biopolymer adhesion
Phys. Biol., 6 (2), 025004 (2009). https://doi.org/10.1088/1478-3975/6/2/025004
M. Mickler, M. Hessling, C. Ratzke, J. Buchner & T. Hugel
The large conformational changes of Hsp90 are only weakly coupled to ATP-hydrolysis
Nat Struct Mol Biol, 16, 281 (2009). https://doi.org/10.1038/nsmb.1557
2008
M. Mickler, E. Schleiff & T. Hugel
From biological towards artificial molecular motors
ChemPhysChem, 9 (11), 1503 (2008). https://doi.org/10.1002/cphc.200800216
D. Horinek, A. Serr, M. Geisler, T. Pirzer, U. Slotta, S.Q. Lud, J.A. Garrido, T. Scheibel, T. Hugel & R.R. Netz
Peptide adsorption on a hydrophobic surface results from an interplay of solvation, surface, and intrapeptide forces
PNAS, 105 (8), 2842 (2008).
M. Geisler, T. Pirzer, C. Ackerschott, S. Lud, J. Garrido, T. Scheibel & T. Hugel
Influence of Hofmeister salts on the adhesion of spider silk proteins onto hydrophobic substrates: an AFM-based single molecule study
Langmuir, 24 (4), 1350 (2008). https://doi.org/10.1021/la702341j
M. Mickler & T. Hugel
Von molekularen Motoren zu künstlichen Nanomaschinen
Physik in unserer Zeit, 39 (1), 14 (2008). https://doi.org/10.1002/piuz.200601157
2007
T. Hugel, J. Michaelis, C. Hetherington, P.J. Jardine, S. Grimes, J.M. Walter, W. Falk, D.L. Anderson & C. Bustamante
Experimental test of connector rotation during DNA packaging into bacteriophage phi29 capsids
PLoS Biol, 5(3): e59 (2007). https://doi.org/10.1371/journal.pbio.0050059
2006
G. Neuert, T. Hugel, R.R. Netz & H.E. Gaub
Elasticity of poly(azobenzene-peptides)
Macromolecules, 39 (2), 789 (2006). https://doi.org/10.1021/ma051622d
2005
R. Lugmaier, T. Hugel, M. Benoit & H.E. Gaub
Phase contrast and DIC illumination for AFM hybrids
Ultramicroscopy, 104 (3-4), 255 (2005). https://doi.org/10.1016/j.ultramic.2005.04.008
T. Hugel, M. Rief, H.E. Gaub & R.R. Netz
Enthalpic elasticity of highly stretched single polymers: Quantitative comparison of ab-Initio theory and AFM experiments
Phys. Rev. Lett., 94, 048301 (2005). https://doi.org/10.1103/PhysRevLett.94.048301
2003
M. Seitz, C. Friedsam, W. Jöstl, T. Hugel & H.E. Gaub
Probing surfaces with single polymers
ChemPhysChem, 4 (9), 986 (2003). https://doi.org/10.1002/cphc.200300760
N.B. Holland, T. Hugel, G. Neuert, D. Oesterhelt, L. Moroder, M. Seitz & H.E. Gaub
Single molecule force spectroscopy of azobenzene polymers: switching elasticity of single photochromic macromolecules
Macromolecules, 36 (6), 2015 (2003). https://doi.org/10.1021/ma021139s
D.W. Urry, T. Hugel, M. Seitz, H.E. Gaub, L. Sheiba, J. Dea, J. Xu, L. Hayes, F. Prochazka & T. Parker
Elastomeric proteins
Ed.: P. R. Shewry, A. S. Tatham, A. J. Bailey, Ideal Protein Elasticity: Elastin Models, Cambridge University Press (2003).
2002
T. Hugel, N.B. Holland, A. Cattani, L. Moroder, M. Seitz & H.E. Gaub
Single-molecule optomechanical cycle
Science, 296 (5570), 1103 (2002). https://doi.org/10.1126/science.1069856
M. Seitz, T. Hugel & H.E. Gaub
Ein lichtgetriebener Molekülmotor
Spektrum der Wissenschaft, 10, 14 (2002).
M. Seitz, T. Hugel, N.B. Holland & H.E. Gaub
Nanotechnology toward the organic photonics
H. Sasabe, GOOTech Ltd. Chitose, Single Molecule Force Spectroscopy by AFM-Related Techniques, Japan (2002)
D.W. Urry, T. Hugel, M. Seitz, H.E. Gaub, L. Sheiba, J. Dea, J. Xu & T. Parker
Elastin: a representative ideal protein elastomer
Philos Trans R Soc Lond B Biol Sci., 357 (1418), 169 (2002). https://doi.org/10.1098/rstb.2001.1023
2001
T. Hugel & M. Seitz
The study of molecular interactions by AFM force spectroscopy
Macromol. Rapid Commun., 22 (13), 989 (2001). https://doi.org/10.1002/1521-3927(20010901)22:13<989::AID-MARC989>3.0.CO;2-D
T. Hugel, M. Grosholz, H. Clausen-Schaumann, A. Pfau, H.E. Gaub & M. Seitz
Elasticity of single polyelectrolyte chains and their desorption from solid supports studied by AFM based single molecule force spectroscopy
Macromolecules, 34 (4), 1039 (2001). https://doi.org/10.1021/ma0009404
2000
B. Heck, T. Hugel, M. Iijima & G. Strobl
Steps in the formation of the partially crystalline state
Polymer, 41 (25), 8839 (2000). https://doi.org/10.1016/S0032-3861(00)00227-5
1999
B. Heck, T. Hugel, M. Iijima, E. Sadiku & G. Strobl
Steps in the transition of an entangled polymer melt to the partially crystalline state
New J. of Phys., 1, 17.1 (1999). https://doi.org/10.1088/1367-2630/1/1/317
T. Hugel, G. Strobl & R. Thomann
Building lamellae from blocks: The pathway followed in the formation of crystallites of syndiotactic polypropylene
Acta Polymerica, 50 (5-6), 214 (1999). https://doi.org/10.1002/(SICI)1521-4044(19990501)50:5/6<214::AID-APOL214>3.0.CO;2-I