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Sophie Weyrauch

PhD student / Doktorandin

Institute of Physical Chemistry
Albertstraße 21
79104 Freiburg

 

Phone: +49 761 203-6228
Room:  01.002  1.OG Flachbau

Email: sophie.weyrauch@physchem.uni-freiburg.de

 

About me:

since 2022: PhD student at the Institute of Physical Chemistry in the Hugel lab

2019 - 2022: Master of Science in Biology (Microbial and Plant Biotechnology) at the Technical University Kaiserslautern

2021 - 2022: External Internship and Master Thesis at the University of Graz, Austria in the Department of Membrane Biophysics

2020: Research Internship at the Institute of Physical Chemistry of the Czech Academy of Sciences in Prague, Czech Republic

2015 - 2019: Bachelor of Science in Biosciences at the Technical University of Kaiserslautern

 

Research interest:

We aim to gain insights in the signalling and formation of phase separation (i.e. areas with higher concentration levels cpmared to the surrounding environment) in real-time in living cells by investigating mammalian cells in a custom-built optimized HILO (highly inclined and laminated optical sheet) fluorescence microscope. This is of interest, since several diseases, like cancer are mediated by phase separation and are involved in stress responses, transcriptional regulation and other regulatory processes in the cell.

We want to capture the pre-condensate state and therefore use low expression conditions with low laser power in our microscope to investigate the formation of those 'clusters' by almost single-molecule resolution. Furthermore, we want to shed light on the factors that drive signalling in condensate formation.

 

Publications:

  • C. Lan, J. Kim, S. Ulferts, F. Aprile-Garcia, S. Weyrauch, A. Anandamurugan, R. Grosse, R. Sawarkar, A. Reinhardt & T. Hugel

     Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation
     Nat. Commun., 14, 4831 (2023). https://doi.org/10.1038/s41467-023-40540-2