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Mathäus Tschaikowsky

PhD student / Doktorand

Mathäus Tschaikowsky

Institute of Physical Chemistry
Albertstraße 21
79104 Freiburg


Phone: +49 761 203-96705
Room:  01.005 Flachbau




Osteoarthritis is a major burden for patients and health care systems and still the most common cause of disability. In cooperation with G.E.R.N. lab (Universitätsklinikum Freiburg) we study the nanomechanical and morphological changes in human articular cartilage (AC) at the early stages of disease. Using Atomic Force Microscopy (AFM) in combination with fluorescence microscopy we are gaining insights into the pathology of the tissue on a nanometer scale.




About me:

  • 06/20: Doctoral scholarship from the German Academic Scholarship Foundation (Studienstiftung des deutschen Volkes)
  • 07/19: Alumni award of the Faculty of Chemistry and Pharmacy, Albert-Ludwigs-Universität Freiburg
  • since 11/2018: PhD student in the Hugel Group
  • 10/18: MSc Biochemistry and Biophysics (very good with honors), Albert-Ludwigs-Universität Freiburg                          Topic: Nanomechanical properties of human osteoarthritic cartilage
    AK Prof. Dr. Hugel and AG Prof. Dr. Bernd Rolauffs (G.E.R.N. lab)
  • 10/16: BSc Chemistry, Albert-Ludwigs-Universität Freiburg and ETH Zürich



  • Tschaikowsky, M., Selig, M., Brander, S., Balzer, B. N., Hugel, T. & Rolauffs, B.
    Proof-of-concept for the detection of early osteoarthritis pathology by clinically applicable endomicroscopy and quantitative AI-supported optical biopsy. Osteoarthritis and Cartilage (2020) (in press) Online:
  • Tschaikowsky, M., Neumann, T., Brander, S., Haschke, H., Rolauffs, B., Balzer, B. N. & Hugel, T. Hybrid fluorescence-AFM probes articular surface degeneration in early osteoarthritis across length scales (2020) (under review)



  • 07/19: Poster award for “Towards a mechanistic understanding and detection of early-onset osteoarthritis” (Tag der Forschung, Freiburg)