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Julia Schimpf

Julia Schimpf

PhD student / Doktorandin


Institute of Physical Chemistry
Albertstraße 21
79104 Freiburg

 

Phone: +49 761 203-6228
Room:  01.002  1.OG Flachbau

Email: 

 

 

Having studied chemistry and English to become a teacher, I became enthusiastic about the work in the field of smFRET (single molecule Förster Resonance Energy Transfer) during my “Zulassungsarbeit”. Being able to observe single molecules has fascinated me ever since and this enthusiasm made me want to learn even more.

Now, as a PhD student, I am not only part of the greatest team I could possibly imagine, but also of the SFB1381, that focuses on protein machineries. I am particularly interested in the heat shock protein 90 (Hsp90). Together with the cell division cycle protein 37 (Cdc37), its homodimers form a protein machinery that is responsible for chaperoning most cellular kinases. Single molecule FRET allows us to follow the assembly, disassembly and conformational changes of these components in real time in an in vitro system. Working on a 4-colour-smFRET-TIRF setup, I want to find out how the dynamics within the Hsp90-Cdc37 complexes achieve controlled chaperoning. At first, I will focus mainly on the question whether the organisation of the Hsp90:Cdc37:Kinase complex is sequential or random. Afterwards other questions can be addressed (e.g., in how far organisation can be controlled and how kinase function is affected by that).